Sara Mattson, Ph.D.
Technical Specialist

Sara Mattson, Ph.D., is a Technical Specialist. Her practice includes patentability assessment and patent procurement in the chemical, pharmaceutical, and biotechnology arts.

Dr. Mattson’s doctoral studies focused on the development of novel directed evolution schemes to enhance the fluorescence of small ultra-red fluorescent protein (smURFP) in mammalian and bacterial cells. She created a method that produces a library of billions of unique fluorescent protein variants using error-prone polymerase chain reaction (PCR). Fluorescence-activated cell sorting (FACS) is then used to rapidly screen the library and automatically select the brightest cells. The final fluorescent protein produced, high-definition smURFP (HDsmURFP), is twelve-fold brighter in human cells than smURFP WT.

Her technical areas of expertise include biochemistry, bioanalytical chemistry, analytical mass spectrometry, and organic chemistry.

In her spare time, she enjoys baking, cooking, and knitting.

Publications

• Sara Mattson, Geraldine N. Tran, Erik A. Rodriguez, “Evolution of the Small Ultra-Red Fluorescent Protein in Bacteria”, Methods in Molecular Biology, 2022, 2564.

• Diaa Shakleya, Sonal Mazumder, Naresh Pavurala, Sara Mattson, Patrick Faustino, “Application of Gas Chromatography for the Analysis of Residual Solvents in Transdermal Drug Delivery Systems (TDS)”, Current Pharmaceutical Analysis, 2022, 18.

• Ellen A. Wood, Sylwia A Stopka, Linwen Zhang, Sara Mattson, Gabor Maasz, Zsolt Pirger, Akos Vertes, “Neuropeptide Localization in Lymnaea stagnalis: From the Central Nervous System to Subcellular Compartments”, Frontiers in Molecular Neuroscience, 2021, 14, 670303.

• Michael J. Taylor, Sara Mattson, Andrey Liyu, Sylwia A. Stopka, Yehia M. Ibrahim, Akos Vertes, Christopher R. Anderton, “Optical Microscopy-Guided Laser Ablation Electrospray Ionization Ion Mobility Mass Spectrometry: Ambient Single Cell Metabolomics with Increased Confidence in Molecular Identification”, Metabolites, 2021, 11, 200.

• Sonal Mazumder, Diaa Shakleya, Sara Mattson, Ashraf Muhammad, Patrick Faustino, Naresh Pavurala, “Influence of Residual Solvents on the Physical Properties of Transdermal Drug Delivery Systems”, International Journal of Pharmaceutics, 2020, 588, 119713.